abstract：:Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar ra...

journal_title：General physiology and biophysics

authors： Miloradović Z,Mihailović-Stanojević N,Jovović Đ,Ivanov M,Vajić UJ,Karanović D,Grujić Milanović J

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of resveratrol on cytogenetic damages of iododeoxyuridine (IUdR) and x-ray megavoltage radiation (6 MV) in spheroid model of U87MG glioblastoma cancer cell line using clonogenic and alkaline comet assay. Cells were cultured as spheroids (350 µm) that were treated wi...

journal_title：General physiology and biophysics

authors： Firouzi F,Khoei S,Mirzaei HR

更新日期：2015-01-01 00:00:00

abstract：:The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three β-adrenoceptors (β-AR) in rat right heart ventricles exposed to acute (1 session) and repeated (7 sessions...

journal_title：General physiology and biophysics

authors： Tillinger A,Novakova M,Krizanova O,Kvetnansky R,Myslivecek J

更新日期：2014-01-01 00:00:00

abstract：:Diabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was ...

journal_title：General physiology and biophysics

authors： Donmez BO,Ozturk N,Sarikanat M,Oguz N,Sari R,Ozdemir S

更新日期：2014-01-01 00:00:00

abstract：:The hormone leptin, by binding to hypothalamic receptors, suppresses food intake and decreases body adiposity. Leptin receptors are also widely expressed in extra-hypothalamic areas such as hippocampus, amygdala and cerebellum, where leptin modulates synaptic transmission. Here we show that a defective leptin receptor...

journal_title：General physiology and biophysics

authors： Forero-Vivas ME,Hernández-Cruz A

更新日期：2014-01-01 00:00:00

abstract：:The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...

journal_title：General physiology and biophysics

authors： Yaman MO,Guner I,Uzun H,Sahin G,Yelmen N

更新日期：2014-01-01 00:00:00

abstract：:The crystallization behaviour of the highly thermostable glucose isomerase from the Streptomyces sp. strain isolated from Tunisian soil was investigated using ammonium sulfate as a precipitating agent. We established phase diagrams at different temperatures and protein concentrations. It was found that the solubility ...

journal_title：General physiology and biophysics

authors： Borgi MA,Rhimi M,Kadri A

更新日期：2014-01-01 00:00:00

abstract：:Aquaporin attracted attention not only of physiologists and biophysicists, but also of chemical engineers. Here we critically analyze a paper describing aquaporin-based artificial membranes, suggested for forward osmosis-based water purification (Wang et al. 2012, Small 8, pp. 1185-1190). Related papers published late...

journal_title：General physiology and biophysics

authors： Kocherginsky N

更新日期：2013-12-01 00:00:00

abstract：:The purpose of this study was to assess the possible protective effects of Artemisia campestris against fenthion-induced nephrotoxicity in adult rats and their progeny. Fenthion was administered orally at a dose of 551 ppm, which represented ¼ of LD50, for 21 consecutive days to pregnant and lactating rats. Oxidative ...

journal_title：General physiology and biophysics

authors： Sefi M,Troudi A,Hamida FB,Soudani N,Boudawara T,Zeghal N

更新日期：2013-12-01 00:00:00

abstract：:Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused ...

journal_title：General physiology and biophysics

authors： Krizova L,Kollar B,Jezova D,Turcani P

更新日期：2013-12-01 00:00:00

abstract：:Although the A1 adenosine receptor (A1 receptor), the main adenosine receptor type in cardiac muscle, is involved in powerful cardioprotective processes such as ischemic preconditioning, the atrial A1 receptor reserve has not yet been quantified for the direct negative inotropic effect of adenosine. In the present stu...

journal_title：General physiology and biophysics

authors： Kiss Z,Pak K,Zsuga J,Juhasz B,Varga B,Szentmiklosi AJ,Haines DD,Tosaki A,Gesztelyi R

更新日期：2013-09-01 00:00:00

abstract：:We studied the involvement of O2, pH and low molecular thiols in H2S-induced decomposition of S-nitrosoglutathione (GSNO). The GSNO decomposition - •NO release was evaluated by UV-VIS spectroscopy and Griess assay. The H2S donor Na2S was used. O2 slightly increased, but was not necessary for the H2S-induced GSNO decom...

journal_title：General physiology and biophysics

authors： Grman M,Misak A,Jacob C,Tomaskova Z,Bertova A,Burkholz T,Docolomansky P,Habala L,Ondrias K

更新日期：2013-09-01 00:00:00

abstract：:Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, gui...

journal_title：General physiology and biophysics

authors： Paulova H,Stracina T,Jarkovsky J,Novakova M,Taborska E

更新日期：2013-06-01 00:00:00

abstract：:We studied physical properties of the monolayers and bilayer lipid membranes (BLM) formed by calix[6]arene carboxylic acid derivative (CX) and its mixtures with diphytanoylphosphatidylcholine (DPhPC) by means of measurement surface pressure, surface dipole potential and electrostriction. CX forms stable monolayers at ...

journal_title：General physiology and biophysics

authors： Vitovič P,Subjaková V,Hianik T

更新日期：2013-06-01 00:00:00

abstract：:Cochlear spiral ganglion neurons provide the only pathway for transmitting sound evoked activity from the hair cells to the central auditory system. Serotonin plays a role in the response properties of central auditory neurons. However, knowledge about the role of serotonin in the peripheral auditory nervous system re...

journal_title：General physiology and biophysics

authors： Yu C,Liu J,Chen Y,Tang Y

更新日期：2013-03-01 00:00:00

abstract：:This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabeti...

journal_title：General physiology and biophysics

authors： Soufi FG,Vardyani M,Sheervalilou R,Mohammadi M,Somi MH

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to assess whether an endothelin-A receptor (ETA-R) blocker, BQ123, or an endothelin-B (ETB-R) receptor blocker, BQ788, influences nuclear factor kappa beta (NF-κB) pathway, free radical generation, tumor necrosis factor-alpha (TNF-α) concentration, and glutathione redox system in hearts obtai...

journal_title：General physiology and biophysics

authors： Piechota-Polanczyk A,Kleniewska P,Gorąca A

更新日期：2012-09-01 00:00:00

abstract：:The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant a...

journal_title：General physiology and biophysics

authors： Riljak V,Maresova D,Jandova K,Bortelova J,Pokorny J

更新日期：2012-06-01 00:00:00

abstract：:Quercetin and epigallocatechin gallate are two of the most abundant polyphenols in dietary plants, including apples, onions, red wine and green tea. The bioactivity of polyphenols is linked to their ability to interact with cell membranes without being internalized. The aim of the present study was to assess the short...

journal_title：General physiology and biophysics

authors： Margina D,Ilie M,Manda G,Neagoe I,Mocanu M,Ionescu D,Gradinaru D,Ganea C

更新日期：2012-03-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) and related peripheral neuropathies are the most commonly inherited neurological disorders in humans, characterized by clinical and genetic heterogeneity. The most prevalent clinical entities belonging to this group of disorders are CMT type 1A (CMT1A) and hereditary neuropathy with l...

journal_title：General physiology and biophysics

authors： Resko P,Radvansky J,Odnogova Z,Baldovic M,Minarik G,Polakova H,Palffy R,Kadasi L

更新日期：2011-12-01 00:00:00

abstract：:Photon emissions were measured at ambient temperature (21°C) in complete darkness once per min from cultures of 10(6) cells during the 12 h following removal from 37°C. The energy of emission was about 10(-20) J/s/cell. Of 8 different cell lines, B16-BL6 (mouse melanoma cells) demonstrated the most conspicuous emissio...

journal_title：General physiology and biophysics

authors： Dotta BT,Buckner CA,Cameron D,Lafrenie RF,Persinger MA

更新日期：2011-09-01 00:00:00

abstract：:It is currently believed that the protein folding rate is related to the protein structures and its amino acid sequence. However, few studies have been done on the problem that whether the protein folding rate is influenced by its corresponding mRNA sequence. In this paper, we analyzed the possible relationship betwee...

journal_title：General physiology and biophysics

authors： Li RF,Li H

更新日期：2011-06-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal L cells upon nutrients ingestion, and is currently used for treating diabetes mellitus. It plays an important role in receptor modulation and cross talk with insulin at the coronary endothelium (CE) and cardiomyocytes (CM) in diabetic type...

journal_title：General physiology and biophysics

authors： Barakat GM,Nuwayri-Salti N,Kadi LN,Bitar KM,Al-Jaroudi WA,Bikhazi AB

更新日期：2011-03-01 00:00:00

abstract：:The aim of the study was to examine the effects of epidermal growth factor (EGF) on ram sperm traits following hypothermic storage. Fresh ram ejaculates were diluted in Triladyl extender, pooled and divided into groups according to EGF doses added (0, 100, 200 or 400 ng/ml). Following 72-96 h storage at 4ºC, the sperm...

journal_title：General physiology and biophysics

authors： Makarevich AV,Spalekova E,Olexikova L,Lukac N,Kubovicova E,Hegedusova Z

更新日期：2011-01-01 00:00:00

abstract：:Sodium nitroprusside (SNP) is a nitric oxide (•NO) donor in vitro and in vivo. In this paper the time variation of the intracellular water proton nuclear magnetic resonance (NMR) effective relaxation time T'(2a) in SNP-treated human erythrocyte suspensions, containing 10 mM membrane impermeable paramagnetic MnCl2, has...

journal_title：General physiology and biophysics

authors： Lahajnar G,Sobotič B,Sepe A,Jazbinšek V,Pečar S

更新日期：2010-12-01 00:00:00

abstract：:For characterization of Na(+),K(+)-ATPase, a key enzyme involved in maintenance of intracellular sodium homeostasis, expression of alpha1 subunit and the ATP- and Na(+)-binding properties were investigated by Western blot analysis and by enzyme kinetics, respectively. Previous studies documented time-dependent alterat...

journal_title：General physiology and biophysics

authors： Javorková V,Mézešová L,Vlkovičová J,Vrbjar N

更新日期：2010-09-01 00:00:00

abstract：:Homocysteine (Hcys) may be implicated in different diseases, especially in cardiovascular illnesses. The most reactive form of Hcys is its cyclic thioester-homocysteine thiolactone (HTL), which is formed in plasma and represents up to 0.29% of plasma total Hcys. Recently, it has been observed that Hcys and HTL may mod...

journal_title：General physiology and biophysics

authors： Olas B,Kołodziejczyk J,Malinowska J

更新日期：2010-06-01 00:00:00

abstract：:Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. The aim of our study was to evaluate the effect of the antioxidant stobadine (STB) in comparison with a treatment by a high-dose of alpha-lipoic acid (ALA), on the neurological consequences of chronic hyper...

journal_title：General physiology and biophysics

authors： Skalská S,Kucera P,Goldenberg Z,Stefek M,Kyselová Z,Jariabka P,Gajdosíková A,Klobucníková K,Traubner P,Stolc S

更新日期：2010-03-01 00:00:00

abstract：:S100A1 is a Ca2+-binding protein expressed at high levels in the myocardium. It is thought to modulate the Ca2+ sensitivity of the sarcoplasmic reticulum (SR) Ca2+ release channels (ryanodine receptors or RyRs) and its expression has been shown to be down regulated in various heart diseases. In this study we used S100...

journal_title：General physiology and biophysics

authors： Gusev K,Ackermann GE,Heizmann CW,Niggli E

更新日期：2009-12-01 00:00:00

abstract：:Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice...

journal_title：General physiology and biophysics

authors： Tarabová B,Nováková M,Lacinová L

更新日期：2009-09-01 00:00:00

abstract：:The effect of membrane composition on ethanol partitioning into lipid bilayers was assessed by headspace gas chromatography. A series of model membranes with different compositions have been investigated. Membranes were exposed to a physiological ethanol concentration of 20 mmol/l. The concentration of membranes was 2...

journal_title：General physiology and biophysics

authors： Nizza DT,Gawrisch K

更新日期：2009-06-01 00:00:00

abstract：:Thermal inactivation of peroxidase (POD) in an extract of Picea omorika (Pancić) Purkyne needles initiated by heat treatment was studied. This is the first study of this kind on a conifer species. Non-linear regression analysis was applied on the inactivation rate data, combining Mitscherlich and Arrhenius equations, ...

journal_title：General physiology and biophysics

authors： Laketa D,Bogdanović J,Kalauzi A,Radotić K

更新日期：2009-03-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) is the major antioxidant in mitochondria that protect brain from neuroendocrine stress. Although MnSOD is localized in the mitochondria, the immediate subcellular distribution of MnSOD protein level in the prefrontal cortex and hippocampus of Wistar male rats exposed to acute str...

journal_title：General physiology and biophysics

authors： Filipović D,Zlatković J,Pajović SB

更新日期：2009-01-01 00:00:00

abstract：:Hyperbaric oxygen treatment (HBO) could transiently reverse hypoxia during acute myocardial infarction (AMI). In order to evaluate whether early HBO can identify viable segments after AMI, improvement of wall motion score index (WMSI) after HBO was compared to dobutamine stress echocardiography (DSE). Thirty-one patie...

journal_title：General physiology and biophysics

authors： Dekleva M,Ostojic M,Neskovic A,Mazic S,Vlahovic A,Suzic Lazic J,Dekleva N

更新日期：2009-01-01 00:00:00

abstract：:Hyperlipidemia is found to be associated with changes in fatty acid (FA) profiles. The aim of this study was to investigate the effects of AHA-Step-1 dietary treatment and combination of fibrates (gemfibrozil) with dietary intervention on serum and erythrocyte phospholipid FA composition in human hyperlipidemia. 78 st...

journal_title：General physiology and biophysics

authors： Ristic-Medic D,Suzic S,Vucic V,Takic M,Tepsic J,Glibetic M

更新日期：2009-01-01 00:00:00

abstract：:Arterial base deficit/excess (BD/E) is commonly used marker of metabolic acidosis in critically ill patients, but requires an arterial puncture and blood gas analysis. We hypothesized that serum bicarbonate (HCO3), which can be routinely obtained, strongly correlates with arterial BD/E and provides equivalent predicti...

journal_title：General physiology and biophysics

authors： Surbatovic M,Radakovic S,Jevtic M,Filipovic N,Romic P,Popovic N,Jevdjic J,Grujic K,Djordjevic D

更新日期：2009-01-01 00:00:00

abstract：:Ischemic/reperfusion brain injury (IRI) is a very severe event with the multiple etiopathogenesis. Ischemic preconditioning (IPC) is an important phenomenon of adaptation of CNS to subsequent ischemia. An altered cross-talk between intracellular calcium stores is presumed in the mechanisms of ischemic damage/protectio...

journal_title：General physiology and biophysics

authors： Lehotský J,Racay P,Pavlíková M,Tatarková Z,Urban P,Chomová M,Kovalská M,Kaplán P

更新日期：2009-01-01 00:00:00

abstract：:Recent research has supported a potential role of immune pathology in the etiopathogenesis of schizophrenic. In the CNS various viruses were identified in the brains of schizophrenic patients. Pro-inflammatory cytokines were found to be associated with the stage of disease. Microglial cells were reported to be activat...

journal_title：General physiology and biophysics

authors： Rothermundt M,Ahn JN,Jörgens S

更新日期：2009-01-01 00:00:00

abstract：:The effect of K+ and Na+ on the properties of DNA aptamers that selective binds to fibrinogen (FIBRI) and heparin (HEPA) exosites of human alpha-thrombin was studied by circular dichroism (CD). The complexes of FIBRI-K+ were slightly more stable than HEPA-K+. However, lower stability was observed for HEPA-K+ at presen...

journal_title：General physiology and biophysics

authors： Poniková S,Antalík M,Hianik T

更新日期：2008-12-01 00:00:00

abstract：:Somatostatin analogues are currently used to treat various disorders such as hypersecretion and different neuroendocrine tumors. In this study we examined the effects on the adrenal cortex of somatostatin (SRIH-14) and octreotide administered subcutaneously twice daily for 5 days to adult male rats. Control rats recei...

journal_title：General physiology and biophysics

authors： Trifunović S,Ajdzanović V,Sosić-Jurjević B,Filipović B,Nestorović N,Sekulić M,Milosević V

更新日期：2008-09-01 00:00:00